Multiple Functions of DNA Polymerases
نویسندگان
چکیده
منابع مشابه
Multiple functions of DNA polymerases.
The primary role of DNA polymerases is to accurately and efficiently replicate the genome in order to ensure the maintenance of the genetic information and its faithful transmission through generations. This is not a simple task considering the size of the genome and its constant exposure to endogenous and environmental DNA damaging agents. Thus, a number of DNA repair pathways operate in cells...
متن کاملDatabase of DNA polymerases.
The DNA Polymerase Database (Polbase) is intended to compile the wealth of existing DNA polymerase information from public and private records into an open, searchable database.
متن کاملA unified kinetic mechanism applicable to multiple DNA polymerases.
After extensive studies spanning over half a century, there is little consensus on the kinetic mechanism of DNA polymerases. Using stopped-flow fluorescence assays for mammalian DNA polymerase beta (Pol beta), we have previously identified a fast fluorescence transition corresponding to conformational closing, and a slow fluorescence transition matching the rate of single-nucleotide incorporati...
متن کاملEukaryotic DNA Polymerases
Themajor function ofDNApolymerases is to replicate the genome and thus to allow transmission of genetic information fromone generation to the next. In eukaryotic cells, this takes place during a discrete period (S phase) of interphase, and replicated chromosomes are subsequently segregated to daughter cells during mitosis. As well as replicating DNA, polymerases help to maintain the integrity o...
متن کاملViral DNA Polymerases
Because many viruses are readily amenable to molecular, genetic, and biochemical analyses, and because the replication of certain viruses has been the target of antiviral drug development, a wealth of information has accumulated regarding the structure, functions, properties, and regulation of eukaryotic viral DNA polymerases. Viral DNA polymerases have interesting similarities with eukaryotic ...
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ژورنال
عنوان ژورنال: Critical Reviews in Plant Sciences
سال: 2007
ISSN: 0735-2689,1549-7836
DOI: 10.1080/07352680701252817